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KMID : 1138520070100010079
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Journal of Pharmacopuncture
2007 Volume.10 No. 1 p.79 ~ p.84
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Seo Hyeong-Sik
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Abstract
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Objective : This experimental study was performed to investigate the effect of Coptidis rhizoma extract compared with quantity on Staphylococcus epidermidis that induce keratitis.
Methods : MIC was measured by dropping to 50{mu}l according to density Coptidis rhizoma extract(100%, 10%, 1%, 0.1%) compared with quantity(40g, 80g, 160g). Anti-bacterial potency was measured by the size of inhibition zone with change of volume.
Results : 1. MIC on Staphylococcus epidermidis in Coptidis rhizoma extract was showed anti-bacterial potency compared with quantity and density in 100% and 10% of all samples(40g, 80g, 160g). 2. MIC on Staphylococcus epidermidis in Coptidis rhizoma extract(40g, 80g, 160g) was showed anti-bacterial potency compared with quantity all samples(20{mu}l, 30{mu}l, 40{mu}l, 50{mu}l) in 100% density, but anti-bacterial potency of 80g, 50{mu}l Coptidis rhizoma extract decreased compared with 40g, 50{mu}l. 3. MIC on Staphylococcus epidermidis in 40g Coptidis rhizoma extract was showed in 50{mu}l, 40{mu}l of 10% density, 80g Coptidis rhizoma extract was showed in 50{mu}l of 10% density, 160g Coptidis rhizoma extract was showed in 50{mu}l, 40{mu}l, 30{mu}l of 10% density.
Conclusions : Coptidis rhizoma extract was showed anti-bacterial potency compare with quantity and density. In herbal drug, anti-bacterial potency compare with quantity and density must be studied.
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KEYWORD
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Staphylococcus epidermidis, keratitis, Coptidis rhizoma extract, MIC, Inhibition zone
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